溶酶體絲氨酸蛋白酶DPP2抗體應(yīng)用方法

中文名稱    溶酶體絲氨酸蛋白酶DPP2抗體   

英文名稱    DPP2   

別    名    Dipeptidyl aminopeptidase II; Dipeptidyl peptidase 7; Dipeptidyl peptidase II; DPP II; DPP2; DPP7; DPPII; QPP; Quiescent cell proline dipeptidase.   

供 應(yīng) 商    遠(yuǎn)慕生物  

研究領(lǐng)域    細(xì)胞生物  激酶和磷酸酶     

抗體來源    Rabbit   

克隆類型    Polyclonal   

交叉反應(yīng)    Human, Mouse, Rat,    

產(chǎn)品應(yīng)用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 溶酶體絲氨酸蛋白酶DPP2抗體（石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.   

分 子 量    52kDa   

細(xì)胞定位    細(xì)胞漿 分泌型蛋白    

性    狀    Lyophilized or Liquid   

濃    度    1mg/1ml   

免 疫 原    KLH conjugated synthetic peptide derived from human DPP2   

亞    型    IgG   

純化方法    affinity purified by Protein A   

儲 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide   

保存條件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.   

溶酶體絲氨酸蛋白酶DPP2抗體產(chǎn)品介紹    background:

DPP2 is a serine protease found most abundantly in the lysosome. There is also a non-lysosomal membrane-associated form of DPP2 reported in the rat brain (DPP-II-M), and a soluble form (DPP-II-S). First discovered as an enzyme involved in the terminal steps of protein degradation, and later as an enzyme involved in cell growth and quiescence, DPP2 cleaves N-terminal dipeptides and tripeptides from proteins. DPP2 has a preference for proline in the P1 position, and processes the tripeptides generated by DPP1 (which is unable to cleave if proline is in the P1 position). Some tumor cell lines express elevated DPP2 levels, and serum levels of DPP2 are elevated in some cancer patients, making DPP2 a potential tumor marker. DPP2 levels have been also been reported to be elevated in the cerebral spinal fluid from Parkinson’s patients.

Function:
Plays an important role in the degradation of some oligopeptides.

Subunit:
Homodimer.

Subcellular Location:
Lysosome. Cytoplasmic vesicle. Secreted.

Tissue Specificity:
Detected in seminal plasma (at protein level).

Post-translational modifications:
N-glycosylated.

Similarity:
Belongs to the peptidase S28 family.