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化學試劑 > 生化試劑 > 小分子抑制劑

產(chǎn)品名稱：	ICG-001
產(chǎn)品編號：	AS-0261
別名：	(6R,9aR)-rel-六氫-6-((4-羥基苯基)甲基)-8-(1-萘基甲基)-4,7-二氧代-N-(苯基甲基)-2H-吡嗪并(1,2-a)嘧啶-1(6H)-甲酰胺;(6R,9AR)-REL-六氫-6-[(4-羥基苯基)甲基]-8-(1-萘基甲基)-4,7-二氧代-N-(苯基甲基)-2H-吡嗪并[1,2-A]嘧啶-1(6H)-甲酰胺;(6S,9as)-n-芐基-6-(4-羥基芐基)-8-(萘-1-甲基)-4,7-二氧代八氫-1H-吡嗪o[1,2-a]嘧啶-1-羧酰胺;香紫蘇醇.硬尾醇
英文名：	(6S,9aS)-6-(4-Hydroxybenzyl)-8-[(naphthalen-1-yl)methyl]-4,7-dioxohexahydropyrazino[1,2-a]pyrimidine-1-carboxylic acid N-benzylamide
CAS號：	780757-88-2
分子式：	C₃₃H₃₂N₄O₄
分子量：	548.63

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ICG-001 is a potent and selective Wnt signaling modulator. ICG-001 modulates Wnt signaling and increased the expression of genes beneficial for cardiac regeneration in epicardial cells. ICG-001 binds cAMP-responsive element binding (CREB)-binding protein (CBP) to disrupt its interaction with β-catenin and inhibit CBP function as a coactivator of Wnt/β-catenin-mediated transcription. ICG-001 induces cytotoxicity of multiple myeloma cells in Wnt-independent manner. Note: Chemical structures of ICG-001 and PRI-724 look very close, but they are not the same molecule. Many vendors confused them.