索引：限制過(guò)度增殖相關(guān)蛋白EML4抗體應(yīng)用方法

中文名稱    限制過(guò)度增殖相關(guān)蛋白EML4抗體    

英文名稱    EML4    

別    名    EML4; EML-4; C2orf2; Echinoderm microtubule associated protein like 4; Echinoderm microtubule-associated protein-like 4; ELP 120; ELP120; EMAL4_HUMAN; EMAP 4; EMAP-4; EMAP4; EML 4; eml4; Restrictedly overexpressed proliferation associated protein; Restrictedly overexpressed proliferation-associated protein; Ropp 120; ROPP120.    

供 應(yīng) 商    遠(yuǎn)慕生物     

研究領(lǐng)域    腫瘤  細(xì)胞生物  免疫學(xué)      

抗體來(lái)源    Rabbit    

克隆類型    Polyclonal    

交叉反應(yīng)    Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,     

產(chǎn)品應(yīng)用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 IEM=1:20-200 IGS=1:20-200 GICA=1:20-200 限制過(guò)度增殖相關(guān)蛋白EML4抗體（石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    109kDa    

細(xì)胞定位    細(xì)胞漿     

性    狀    Lyophilized or Liquid    

濃    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human EML4/C2orf180    

亞    型    IgG    

純化方法    affinity purified by Protein A    

儲(chǔ) 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存條件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

限制過(guò)度增殖相關(guān)蛋白EML4抗體產(chǎn)品介紹    background:

Microtubules are components of the Actin cytoskeleton that play crucial roles in cell morphogenesis, cell motility, spindle formation and chromosome movements. Echinoderm microtubule-associated (EML) proteins function to modify the assembly dynamics of microtubules. EML4 (Echinoderm microtubule-associated protein-like 4), also known as EMAPL4, ELP120, C2orf2 or ROPP120, is a 981 amino acid cytoplasmic protein that contains nine WD repeats. Expressed at high levels during mitosis, EML4 is thought to modify the assembly dynamics of microtubules, specifically altering microtubules to become longer and more flexible. Due to a chromosomal inversion with chromosome 2p, EML4 may exist as a fusion protein with ALK (anaplastic lymphoma receptor tyrosine kinase), producing an EML4-ALK fusion complex that plays a role in the pathogenesis of lung cancer.

Function:
May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic (By similarity).

Subcellular Location:
Cytoplasm, cytoskeleton (Potential).

Tissue Specificity:

Similarity:
Belongs to the WD repeat EMAP family.
Contains 9 WD repeats.