索引：EGF毒素受體7跨膜結(jié)構(gòu)域蛋白1抗體說明書

中文名稱    EGF毒素受體7跨膜結(jié)構(gòu)域蛋白1抗體    

英文名稱    ETL    

別    名    EGF; EGF latrophilin and seven transmembrane domain containing 1; EGF TM7 latrophilin related protein; EGF-TM7-latrophilin-related protein; EGFTM7 latrophilin related protein; ELTD 1; ELTD1; ELTD1_HUMAN; ETL; ETL protein; KPG_003; latrophilin and seven transmembrane domain-containing protein 1; zgc:63629.    

供 應(yīng) 商    遠(yuǎn)慕生物    

研究領(lǐng)域    細(xì)胞生物  信號轉(zhuǎn)導(dǎo)  G蛋白偶聯(lián)受體  G蛋白信號  跨膜蛋白      

抗體來源    Rabbit    

克隆類型    Polyclonal    

交叉反應(yīng)    Human, Mouse, Rat, Horse,     

產(chǎn)品應(yīng)用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 ICC=1:100-500 IF=1:100-500 EGF毒素受體7跨膜結(jié)構(gòu)域蛋白1抗體（石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

細(xì)胞定位    細(xì)胞膜     

性    狀    Lyophilized or Liquid    

濃    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human ETL/ELTD1    

亞    型    IgG    

純化方法    affinity purified by Protein A    

儲 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存條件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

EGF毒素受體7跨膜結(jié)構(gòu)域蛋白1抗體產(chǎn)品介紹    background:

The epidermal growth factor (EGF)-TM7 family constitutes a group of leukocyte-restricted, class B G-protein coupled receptors (GPCRs). These include CD97, EMR1(EGF-like molecule containing mucin-like hormone receptor 1, designated F4/80 in mouse), EMR2, EMR3, FIRE, and ETL. These family members are characterized by an extended extracellular region with several N-terminal EGF domains and are predominantly expressed on cells of the immune system. Unlike other GPCRs, neither EMR2 nor EMR3 have mouse orthologs. The molecular twins CD97 and EMR2 only differ by 6 out of 236 amino acids, but this slight difference is enough to alter ligand specificity and confer nonredundant functions. EMR3 may function in myeloid-myeloid interactions during immune and inflammatory responses. ETL is a 738 amino acid protein composed of a large extracellular domain with EGF-like repeats, a seven-transmembrane domain, and a short cytoplasmic tail. ETL mRNA expression is up-regulated in the adult rat and human heart.

Function:
Could be involved in cardiac development.

Subunit:
Forms a heterodimer, consisting of a large extracellular region (alpha subunit) non-covalently linked to a seven-transmembrane moiety (beta subunit). Forms stable dimer at the cells surface (By similarity).

Subcellular Location:
Cell membrane.

Tissue Specificity:
Mainly expressed in smooth muscle.

Post-translational modifications:
Proteolytically cleaved into 2 subunits, an extracellular alpha subunit and a seven-transmembrane subunit.

Similarity:
Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
Contains 2 EGF-like domains.
Contains 1 GPS domain.