上皮粘連調(diào)控蛋白ESRP2抗體產(chǎn)品介紹

中文名稱：上皮粘連調(diào)控蛋白ESRP2 多克隆抗體

英文名字：ESRP2 Polyclonal Antibody

供 應(yīng) 商：遠慕生物

背景資料：ESPR2 is an epithelial cell-type-specific splicing regulator. ESRP2 (Epithelial Splicing Regulatory Protein 2) is a Protein Coding gene. Among its related pathways are Signaling by FGFR2 and mRNA Capping.

宿主物種:兔

交叉反應(yīng):人,小鼠,大鼠,狗,奶牛

克隆類型:多克隆

分 子 量:78kDa

濃 度:1mg/1ml

亞 型:IgG

細胞定位:細胞核

免 疫 原:KLH conjugated synthetic peptide derived from human ESRP2

純化方法:蛋白A親和純化

產(chǎn)品應(yīng)用:WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）

尚未測試其他應(yīng)用;

實際稀釋濃度可根據(jù)用戶的具體用途決定。

儲 存 液:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol

保存條件:4℃運輸，-20℃保存，避免反復(fù)凍融

應(yīng)用領(lǐng)域:細胞生物 細胞粘附分子 細胞類型標(biāo)志物 表觀遺傳學(xué)

保存建議  自發(fā)貨之日起，-20°C可穩(wěn)定保存1年。為最大限度的避免損失，請在打開管蓋之前融化抗體并離心。我們建議使用前分裝以避免反復(fù)凍融。

產(chǎn)品介紹

background:

mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2.

Function:

mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2.

Subcellular Location:

Nucleus.

Tissue Specificity:

Epithelial cell-specific.

Similarity:

Belongs to the ESRP family.

Contains 3 RRM (RNA recognition motif) domains.

Database links:

UniProtKB/Swiss-Prot: Q9H6T0.1

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.