誘捕受體2抗體簡介說明

中文名稱    誘捕受體2抗體 

英文名稱    DcR2

別    名    TNFRSF10D; Decoy receptor 2; CD 264; CD264; CD-264; DcR 2; decoy with truncated death domain; ID; TNF receptor related receptor for TRAIL; TNF related apoptosis inducing ligand receptor 4; TNFRSF 10D; TRAIL R4; TRAIL receptor 4; TRAIL receptor with a truncated death domain; TRAILR4; TRIALR 4; TRUNDD; Tumor necrosis factor receptor superfamily member 10d decoy with truncated death domain; Tumor necrosis factor receptor superfamily member 10D precursor; TR10D_HUMAN.      

研究領(lǐng)域    腫瘤  細(xì)胞生物  免疫學(xué)  細(xì)胞凋亡  細(xì)胞膜受體      

抗體來源    Rabbit    

克隆類型    Polyclonal    

交叉反應(yīng)    Human,     

遠慕生物產(chǎn)品應(yīng)用    WB=1:500-2000 ELISA=1:500-1000 Flow-Cyt=1μg /test  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    36kDa    

細(xì)胞定位    細(xì)胞膜     

性    狀    Lyophilized or Liquid    

濃    度    1mg/ml    

免 疫 原    KLH conjugated synthetic peptide derived from human DcR2:56-160/386 <Extracellular>    

亞    型    IgG    

純化方法    affinity purified by Protein A    

儲 存 液    0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.    

保存條件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

PubMed    PubMed    

遠慕生物產(chǎn)品介紹    Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L, a member of the TNF family, induces apoptosis of a variety of tumor cell lines. DR4 and DR5 are functional receptors for TRAIL, and DcR1/TRID is a decoy receptor. Another member of the TRAIL receptor family was identified and designated DcR2. The DcR2 receptor is 386 amino acids in length and has an extracellular TRAIL binding domain, but lacks intracellular death domain and does not induce apoptosis. Although this receptor binds to the cytotoxic ligand TRAIL, it contains a truncated death domain and functions as an inhibitory receptor. When overexpressed, the DcR2 receptor can protect cells against TRAIL mediated cytotoxicity. Like DR4 and DR5, DcR2 transcript is widely expressed in a variety of normal human tissues but DcR2 is absent in most tumors. Ultraviolet radiation has been shown to upregulate DcR2 expression on human keratinocytes. Over expression of DcR2 attenuated TRAIL induced apoptosis.